Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231934 | 0.95 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3229812 | 0.93 | MAPT (0.51) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3235305 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3230851 | 0.90 | FFAR2 (0.50) | SMN1; SMN2RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL3235879 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3236498 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3224931 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3237560 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL3233720 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1GUCY1B2GUCY1A2 | |
| SCHEMBL3238456 | 0.87 | L3MBTL1 (0.51) | SMN1; SMN2RAB9ANPC1GUCY1B2GUCY1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |