Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.71 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.71 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | BCHE | P06276 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692922 | 0.83 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10899768 | 0.71 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3232103 | 0.70 | CHRNA7 (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10903307 | 0.69 | SLC6A2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL10903199 | 0.69 | SLC6A2 (0.61) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL28872300 | 0.68 | ACHE (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL19756712 | 0.67 | ACHE (0.77) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9170689 | 0.66 | ACHE (0.70) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Ethyne SCHEMBL28710944 | 0.65 | ACHE (0.68) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9910974 | 0.65 | ACHE (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026208-A1 | 1-AZA-BICYCLO[3.3.1]NONANE OR -3-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026208-A1 | 1-AZA-BICYCLO[3.3.1]NONANE OR -3-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | disclosed |