Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241863 | 0.92 | HDAC1 (0.52) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL3236766 | 0.86 | KMT2A (0.44) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL3232140 | 0.80 | HDAC1 (0.84) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL1063952 | 0.79 | HDAC1 (0.58) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL1060811 | 0.78 | HDAC1 (0.60) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL3241868 | 0.78 | HDAC1 (0.69) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL1066979 | 0.78 | HDAC1 (0.58) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL3238553 | 0.77 | HDAC1 (0.44) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL16011052 | 0.76 | HDAC4 (0.60) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL3234097 | 0.76 | HDAC1 (0.48) | HDAC1HDAC3HDAC6HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |