Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24756487 | 0.86 | SCN9A (0.42) | SMN1; SMN2SCN9AKDM5AL3MBTL1L3MBTL3 | |
| SCHEMBL21485443 | 0.83 | CHRNA4 (0.43) | SMN1; SMN2KDM5AL3MBTL1L3MBTL3CHRNB2 | |
| SCHEMBL15649431 | 0.82 | SCN9A (0.44) | SMN1; SMN2SCN9AKDM5AL3MBTL1L3MBTL3 | |
| SCHEMBL13467180 | 0.82 | CCNC (0.50) | SMN1; SMN2SCN9AKDM5APDE10APDK2 | |
| SCHEMBL20254512 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2SCN9ASCN10AL3MBTL1L3MBTL3 | |
| SCHEMBL13467096 | 0.81 | PDE10A (0.56) | SMN1; SMN2SCN9ASCN10AKDM5AL3MBTL1 | |
| SCHEMBL13280171 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1L3MBTL3CCR8KCNH2 | |
| SCHEMBL4063719 | 0.80 | L3MBTL1 (0.51) | SMN1; SMN2L3MBTL1L3MBTL3CCR8KCNH2 | |
| SCHEMBL29618361 | 0.79 | L3MBTL1 (0.50) | SMN1; SMN2L3MBTL1L3MBTL3CCR8KCNH2 | |
| SCHEMBL1758990 | 0.79 | L3MBTL1 (0.50) | SMN1; SMN2L3MBTL1L3MBTL3CCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |