Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 7/20 | 0.39 |
| ▸ | INPP5A | Q14642 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | INPP5B | P32019 | 2/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32660808 | 0.89 | INPPL1 (0.39) | INPPL1INPP5AAKT1INPP5BCTRC | |
| SCHEMBL381664 | 0.87 | INPPL1 (0.42) | INPPL1INPP5AAKT1INPP5BCTRC | |
| SCHEMBL31296012 | 0.87 | INPPL1 (0.42) | INPPL1INPP5AAKT1INPP5BCTRC | |
| SCHEMBL1726003 | 0.85 | INPPL1 (0.41) | INPPL1INPP5AAKT1INPP5BCTRC | |
| SCHEMBL29892389 | 0.81 | TYR (0.42) | INPPL1INPP5AAKT1HTR2AHTR2C | |
| SCHEMBL11128600 | 0.81 | TYR (0.42) | INPPL1INPP5AAKT1HTR2AHTR2C | |
| SCHEMBL290843 | 0.81 | TYR (0.42) | INPPL1INPP5AAKT1HTR2AHTR2C | |
| SCHEMBL8958556 | 0.81 | TYR (0.42) | INPPL1INPP5AAKT1HTR2AHTR2C | |
| SCHEMBL9329182 | 0.81 | TYR (0.42) | INPPL1INPP5AAKT1HTR2AHTR2C | |
| SCHEMBL4427146 | 0.81 | INPPL1 (0.45) | INPPL1INPP5AAKT1INPP5BCTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180104263-A1 | BUTYRYLCHOLINESTERASE INHIBITORS | JAL THERAPEUTICS, LLC | 2018-04-19 | — | — | US | disclosed |
| EP-2097428-B1 | BUTYRYLCHOLINESTERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | MGP BIOTECHNOLOGIES INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-9757399-B2 | Butyrylcholinesterase inhibitors | JAL THERAPEUTICS, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160206635-A1 | Butyrylcholinesterase Inhibitors | JAL THERAPEUTICS, LLC | 2016-07-21 | — | — | US | disclosed |
| US-20140073608-A1 | Butyrylcholinesterase Inhibitors | MGP BIOTECHNOLOGIES, LLC (US) | 2014-03-13 | — | — | US | disclosed |
| US-20100069337-A1 | BUTYRYLCHOLINESTERASE INHIBITORS | JAL THERAPEUTICS, LLC | 2010-03-18 | — | — | US | disclosed |
| EP-2097428-A2 | BUTYRYLCHOLINESTERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Mgp Biotechnologies, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008055249-A2 | BUTYRYLCHOLINESTERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | MGP BIOTECHNOLOGIES, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180104263-A1 | BUTYRYLCHOLINESTERASE INHIBITORS | BCHE, ACHE, PSEN1 | INPPL1 120/4885INPP5A 211/4885AKT1 821/4885 |
| US-20160206635-A1 | Butyrylcholinesterase Inhibitors | BCHE, ACHE, PSEN1 | INPPL1 120/4885INPP5A 211/4885AKT1 821/4885 |
| US-20140073608-A1 | Butyrylcholinesterase Inhibitors | BCHE, ACHE, PSEN1 | INPPL1 120/4885INPP5A 211/4885AKT1 821/4885 |
| US-20100069337-A1 | BUTYRYLCHOLINESTERASE INHIBITORS | BCHE, ACHE, PSEN1 | INPPL1 120/4885INPP5A 211/4885AKT1 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.