Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.47 |
| ▸ | FABP7 | O15540 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17413389 | 0.84 | EPHX2 (0.53) | KMT2AEPHX2FABP5FABP7HDAC3 | |
| SCHEMBL31423769 | 0.84 | EPHX2 (0.53) | KMT2AEPHX2FABP5FABP7HDAC3 | |
| SCHEMBL29547309 | 0.84 | EPHX2 (0.53) | KMT2AEPHX2FABP5FABP7HDAC3 | |
| SCHEMBL14701886 | 0.84 | EPHX2 (0.53) | KMT2AEPHX2FABP5FABP7HDAC3 | |
| SCHEMBL29067330 | 0.83 | EPHX2 (0.57) | KMT2AEPHX2FABP5FABP7CHRM3 | |
| SCHEMBL20266541 | 0.83 | KMT2A (0.52) | KMT2AEPHX2FABP5FABP7HDAC3 | |
| SCHEMBL29019441 | 0.83 | EPHX2 (0.49) | KMT2AEPHX2FABP5FABP7CHRM3 | |
| SCHEMBL119223 | 0.82 | EPHX2 (0.60) | KMT2AEPHX2FABP5FABP7CHRM3 | |
| SCHEMBL29401765 | 0.82 | EPHX2 (0.60) | KMT2AEPHX2FABP5FABP7CHRM3 | |
| SCHEMBL29913938 | 0.82 | EPHX2 (0.60) | KMT2AEPHX2FABP5FABP7CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |