⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669497 | 0.65 | — | — | |
| SCHEMBL785509 | 0.63 | MAPT (0.36) | — | |
| SCHEMBL4456000 | 0.63 | — | — | |
| SCHEMBL7531718 | 0.61 | — | — | |
| SCHEMBL10732098 | 0.61 | — | — | |
| SCHEMBL1711999 | 0.58 | — | — | |
| Hydrochloric Acid SCHEMBL8873510 | 0.55 | — | — | |
| SCHEMBL3235164 | 0.54 | MAPT (0.35) | — | |
| SCHEMBL11955386 | 0.52 | TSHR (0.47) | — | |
| SCHEMBL16142754 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| CN-101951777-A | Tetrahydrofuropyridones | MERCK & CO INC | 2011-01-19 | — | — | CN | disclosed |
| CN-101951777-A | Tetrahydrofuropyridones | MERCK & CO INC | 2011-01-19 | — | — | CN | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
| EP-2257170-A1 | TETRAHYDROFUROPYRIDONES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009108496-A1 | TETRAHYDROFUROPYRIDONES | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |