Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628528 | 0.87 | KMT2A (0.70) | KMT2APOLBMTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL13430584 | 0.83 | KMT2A (0.47) | KMT2APOLBMTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL14026722 | 0.80 | KMT2A (0.41) | KMT2APOLBMTNR1AMTNR1BSMN1; SMN2 | |
| 1,2-Dimethoxybenzene SCHEMBL31501593 | 0.76 | CA1 (0.61) | KMT2APOLBSMN1; SMN2HTTLMNA | |
| 1,2-Dimethoxybenzene SCHEMBL3661985 | 0.76 | CA1 (0.61) | KMT2APOLBSMN1; SMN2HTTLMNA | |
| SCHEMBL9423878 | 0.76 | KMT2A (0.46) | KMT2ASMN1; SMN2HTTLMNACYP2D6 | |
| SCHEMBL9424144 | 0.75 | L3MBTL1 (0.61) | KMT2ALMNAALDH1A1KDM4EGAA | |
| SCHEMBL3228799 | 0.73 | KMT2A (0.57) | KMT2APOLBMTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL8434636 | 0.73 | KMT2A (0.47) | KMT2ALMNACYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL23829938 | 0.72 | HTT (0.59) | KMT2AHTTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080549-B2 | Endothelin receptor antagonists | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20100063076-A1 | Endothelin receptor antagonists | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063076-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | KMT2A 3852/4885POLB 3137/4885MTNR1A 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.