Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234418 | 0.89 | CHRM1 (0.61) | CHRM1SMN1; SMN2GAATOP1LMNA | |
| SCHEMBL3235484 | 0.89 | CHRM1 (0.52) | CHRM1SMN1; SMN2GAALMNATDP1 | |
| SCHEMBL3234583 | 0.87 | CHRM1 (0.75) | CHRM1LMNA | |
| SCHEMBL3236188 | 0.86 | CHRM1 (0.69) | CHRM1LMNA | |
| SCHEMBL3234283 | 0.86 | CHRM1 (0.65) | CHRM1SMN1; SMN2GAATOP1LMNA | |
| SCHEMBL3232230 | 0.86 | CHRM1 (0.74) | CHRM1SMN1; SMN2LMNA | |
| SCHEMBL2880256 | 0.85 | CHRM1 (0.76) | CHRM1SMN1; SMN2TOP1LMNATDP1 | |
| SCHEMBL3237954 | 0.83 | CHRM1 (0.73) | CHRM1TOP1LMNA | |
| SCHEMBL2487094 | 0.83 | CHRM1 (0.80) | CHRM1SMN1; SMN2TOP1LMNA | |
| SCHEMBL3234190 | 0.83 | CHRM1 (0.67) | CHRM1GAALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | claimed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | disclosed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |