Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234589 | 0.89 | CHRM1 (0.55) | CHRM1SMN1; SMN2LMNAP2RX7 | |
| SCHEMBL3234425 | 0.89 | CHRM1 (0.48) | CHRM1SMN1; SMN2GAAP2RX7SLC5A1 | |
| SCHEMBL3235478 | 0.89 | CHRM1 (0.67) | CHRM1TDP1SMN1; SMN2GAALMNA | |
| SCHEMBL3234289 | 0.88 | CHRM1 (0.49) | CHRM1SMN1; SMN2GAALMNASLC5A1 | |
| SCHEMBL3232234 | 0.88 | CHRM1 (0.56) | CHRM1SMN1; SMN2LMNASLC5A1SLC5A2 | |
| SCHEMBL3236193 | 0.87 | CHRM1 (0.53) | CHRM1SMN1; SMN2LMNA | |
| SCHEMBL3237961 | 0.86 | CHRM1 (0.54) | CHRM1SMN1; SMN2LMNAP2RX7 | |
| SCHEMBL3240976 | 0.85 | CHRM1 (0.56) | CHRM1TDP1SMN1; SMN2DBHLMNA | |
| SCHEMBL2492203 | 0.85 | CHRM1 (0.61) | CHRM1SMN1; SMN2LMNASLC5A1SLC5A2 | |
| SCHEMBL3234399 | 0.85 | CHRM1 (0.63) | CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |