Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.66 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.66 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.66 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.59 |
| ▸ | CHRNA6 | Q15825 | 4/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.49 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236529 | 0.97 | CHRNB2 (0.66) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL3239097 | 0.93 | CHRNB2 (0.75) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711084 | 0.87 | CHRNB2 (0.87) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL3226809 | 0.84 | CHRNB2 (0.58) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711199 | 0.83 | CHRNB2 (0.87) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711336 | 0.83 | CHRNB2 (0.87) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL13833626 | 0.81 | CHRNB2 (0.68) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711592 | 0.79 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711532 | 0.79 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL1711180 | 0.79 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |