Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28416837 | 0.90 | TSHR (0.50) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL4486338 | 0.86 | TSHR (0.62) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL4623846 | 0.86 | — | — | |
| SCHEMBL4895623 | 0.86 | TSHR (0.68) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL15245 | 0.86 | — | — | |
| SCHEMBL2933673 | 0.86 | — | — | |
| SCHEMBL2933671 | 0.86 | — | — | |
| SCHEMBL1130097 | 0.85 | TSHR (0.50) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL7874503 | 0.84 | TSHR (0.45) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL216280 | 0.83 | TSHR (0.65) | TSHRALDH1A1MAPK1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072696-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | NATIONAL SCIENCE FOUNDATION | 2018-03-15 | — | — | US | disclosed |
| US-9676743-B2 | Substituted 3-hydroxy-δ-lactones from epoxides | CORNELL UNIVERSITY (US) | 2017-06-13 | — | — | US | disclosed |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | CORNELL UNIVERSITY (US) | 2014-04-17 | — | — | US | disclosed |
| US-8530677-B2 | Substituted 3-hydroxy-delta-lactones from epoxides | CORNELL UNIVERSITY (US) | 2013-09-10 | — | — | US | disclosed |
| US-20100145046-A1 | Substituted 3-hydroxy-delta-lactones from epoxides | ENERGY, UNITED STATES DEPARTMENT OF | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145046-A1 | Substituted 3-hydroxy-delta-lactones from epoxides | EBP, CYP8B1, HSD3B2 | TSHR 4202/4885ALDH1A1 319/4885MAPK1 4592/4885 |
| US-20180072696-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | EBP, CYP8B1, HSD3B2 | TSHR 4202/4885ALDH1A1 319/4885MAPK1 4592/4885 |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | EBP, CYP8B1, HSD3B2 | TSHR 4202/4885ALDH1A1 319/4885MAPK1 4592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.