Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.71 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236171 | 0.84 | ESR1 (0.69) | ESR1ESR2TAAR1SLC6A2MEN1 | |
| SCHEMBL3234292 | 0.81 | ESR1 (0.56) | ESR1ESR2ARSLC6A2CYP1A2 | |
| SCHEMBL13093046 | 0.81 | ESR1 (0.44) | ESR1ESR2ARALDH1A1 | |
| SCHEMBL3680722 | 0.80 | ESR1 (0.50) | ESR1ESR2TAAR1SLC6A2MEN1 | |
| SCHEMBL22500212 | 0.79 | ESR1 (0.70) | ESR1ESR2ARSLC6A2MEN1 | |
| SCHEMBL156611 | 0.78 | ESR1 (0.47) | ESR1ESR2ARSLC6A2CYP1A2 | |
| SCHEMBL3236053 | 0.78 | ESR1 (0.69) | ESR1ESR2ARSLC6A2MEN1 | |
| SCHEMBL28081438 | 0.77 | ESR1 (0.41) | ESR1ESR2ARCYP2C9CYP2C19 | |
| SCHEMBL14995802 | 0.76 | ESR1 (0.57) | ESR1ESR2ARTAAR1SLC6A2 | |
| SCHEMBL3873634 | 0.75 | GAA (0.47) | ESR1ESR2ARMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | claimed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |