Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GNRHR | P30968 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747226 | 0.88 | CHRM1 (0.50) | CHRM1TDP1GNRHRHTTKDM4E | |
| SCHEMBL2884792 | 0.85 | CHRM1 (0.64) | CHRM1TDP1KDM4EALDH1A1 | |
| SCHEMBL6691224 | 0.83 | TDP1 (0.55) | CHRM1TDP1HTTKDM4EALDH1A1 | |
| SCHEMBL3234195 | 0.82 | CHRM1 (0.58) | CHRM1TDP1GNRHRHTTKDM4E | |
| SCHEMBL3234568 | 0.81 | CHRM1 (0.51) | CHRM1TDP1GNRHRHTTKDM4E | |
| SCHEMBL2492043 | 0.79 | LMNA (0.51) | CHRM1TDP1GNRHRHTTKDM4E | |
| SCHEMBL3238772 | 0.78 | CHRM1 (0.44) | CHRM1TDP1HTTKDM4EALDH1A1 | |
| SCHEMBL16378027 | 0.77 | CHRM1 (0.76) | CHRM1GNRHRHTTKDM4EALDH1A1 | |
| SCHEMBL1931751 | 0.77 | CHRM1 (0.60) | CHRM1TDP1GNRHRHTTKDM4E | |
| SCHEMBL3234254 | 0.76 | CHRM1 (0.59) | CHRM1GNRHRHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2007100366-A2 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |