Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 6/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237168 | 0.92 | CHRM1 (0.66) | CHRM1LMNAPDE7APDE4A | |
| SCHEMBL3236683 | 0.92 | CHRM1 (0.66) | CHRM1LMNAPDE7APDE4A | |
| SCHEMBL3232279 | 0.86 | CHRM1 (0.82) | CHRM1LMNA | |
| SCHEMBL2882158 | 0.85 | CHRM1 (0.68) | CHRM1LMNAPDE7APDE4A | |
| SCHEMBL2490523 | 0.84 | CHRM1 (1.00) | CHRM1LMNA | |
| SCHEMBL3237312 | 0.82 | CHRM1 (0.76) | CHRM1LMNA | |
| SCHEMBL3235201 | 0.81 | CHRM1 (0.65) | CHRM1LMNA | |
| SCHEMBL1550525 | 0.81 | CHRM1 (0.74) | CHRM1LMNAPDE7APDE4A | |
| SCHEMBL1931218 | 0.81 | CHRM1 (0.74) | CHRM1LMNAPDE7APDE4A | |
| SCHEMBL2283690 | 0.81 | CHRM1 (0.71) | CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |