Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.65 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490472 | 0.86 | CHRM1 (0.52) | CHRM1RORCMAPTNPC1RAB9A | |
| SCHEMBL2486523 | 0.84 | CHRM1 (0.58) | CHRM1RORCAKR1B1MEN1CYP1A2 | |
| SCHEMBL3238778 | 0.84 | CHRM1 (0.48) | CHRM1RORCAKR1B1MAPTTP53 | |
| SCHEMBL15111959 | 0.82 | NPC1 (0.58) | RORCAKR1B1MAPTNPC1RAB9A | |
| SCHEMBL3237399 | 0.81 | CHRM1 (0.72) | CHRM1LMNA | |
| SCHEMBL3230356 | 0.80 | IDO1 (0.50) | CHRM1AKR1B1MAPTRAB9ALMNA | |
| SCHEMBL3237168 | 0.79 | CHRM1 (0.66) | CHRM1LMNA | |
| SCHEMBL2489633 | 0.79 | CHRM1 (0.71) | CHRM1RORCTP53RXFP1 | |
| SCHEMBL2490478 | 0.79 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL3233862 | 0.78 | AKR1B1 (0.56) | CHRM1AKR1B1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | claimed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |