Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 16/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376183 | 0.88 | EIF2AK4 (0.49) | EIF2AK4FLT3EGFRBTK | |
| SCHEMBL376184 | 0.79 | EIF2AK4 (0.46) | EIF2AK4 | |
| SCHEMBL376271 | 0.79 | IRAK4 (0.57) | FLT3 | |
| SCHEMBL10239890 | 0.79 | IRAK4 (0.57) | FLT3 | |
| SCHEMBL376565 | 0.77 | FLT3 (0.58) | FLT3 | |
| SCHEMBL31000122 | 0.77 | EIF2AK4 (0.43) | EIF2AK4FLT3 | |
| SCHEMBL15203452 | 0.74 | FLT3 (0.39) | EIF2AK4FLT3 | |
| SCHEMBL15203433 | 0.74 | MAPK8 (0.44) | FLT3 | |
| SCHEMBL3233009 | 0.74 | MAPK8 (0.44) | FLT3 | |
| SCHEMBL10239880 | 0.73 | EIF2AK4 (0.44) | EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518952-B2 | 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors | PFIZER INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |