Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 13/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24977595 | 0.89 | HDAC4 (0.38) | EIF2AK4HDAC4HDAC6FLT3TRPV1 | |
| SCHEMBL24977598 | 0.89 | HDAC4 (0.38) | EIF2AK4HDAC4HDAC6FLT3TRPV1 | |
| SCHEMBL376183 | 0.88 | EIF2AK4 (0.49) | EIF2AK4HDAC4HDAC6FLT3SYK | |
| SCHEMBL31000078 | 0.87 | EIF2AK4 (0.46) | EIF2AK4HDAC4HDAC6TRPV1 | |
| SCHEMBL376423 | 0.87 | FLT3 (0.53) | EIF2AK4FLT3 | |
| SCHEMBL376422 | 0.87 | FLT3 (0.53) | EIF2AK4FLT3 | |
| SCHEMBL25998064 | 0.87 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6FLT3TRPV1 | |
| SCHEMBL12552862 | 0.86 | IRAK4 (0.47) | EIF2AK4HDAC4HDAC6FLT3USP30 | |
| SCHEMBL24231691 | 0.85 | SYK (0.43) | EIF2AK4HDAC4HDAC6FLT3SYK | |
| SCHEMBL376257 | 0.84 | IRAK4 (0.45) | HDAC4HDAC6FLT3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |