Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238442 | 0.92 | CHRM1 (0.41) | CHRM1MRGPRX4P2RX7PTGDR2KDM4E | |
| SCHEMBL3234599 | 0.87 | CHRM1 (0.44) | CHRM1MRGPRX4P2RX7ALDH1A1TRAP1 | |
| SCHEMBL3237430 | 0.86 | CHRM1 (0.53) | CHRM1MRGPRX4P2RX7ALDH1A1KDM4E | |
| SCHEMBL2883187 | 0.85 | CHRM1 (0.56) | CHRM1MRGPRX4P2RX7ALDH1A1TRAP1 | |
| SCHEMBL3242122 | 0.82 | CHRM1 (0.48) | CHRM1P2RX7 | |
| SCHEMBL3242155 | 0.82 | CHRM1 (0.45) | CHRM1P2RX7ALDH1A1KDM4E | |
| SCHEMBL3238772 | 0.80 | CHRM1 (0.44) | CHRM1PPARGP2RX7ALDH1A1KDM4E | |
| SCHEMBL3234252 | 0.79 | CHRM1 (0.44) | CHRM1MRGPRX4P2RX7PTGDR2 | |
| SCHEMBL3239024 | 0.77 | CHRM1 (0.57) | CHRM1 | |
| SCHEMBL2877226 | 0.76 | CHRM1 (0.57) | CHRM1MRGPRX4P2RX7ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |