⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344268 | 0.81 | ALDH1A1 (0.32) | — | |
| SCHEMBL979980 | 0.79 | TSHR (0.35) | — | |
| SCHEMBL20836416 | 0.77 | — | — | |
| SCHEMBL1235848 | 0.77 | — | — | |
| SCHEMBL17224246 | 0.77 | — | — | |
| SCHEMBL9427661 | 0.77 | — | — | |
| SCHEMBL11160922 | 0.75 | — | — | |
| SCHEMBL6365268 | 0.75 | — | — | |
| SCHEMBL20504237 | 0.75 | — | — | |
| SCHEMBL1960253 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144534-A1 | CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-11617799-B2 | Cleavable tetrazine used in bio-orthogonal drug activation | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2023-04-04 | — | — | US | disclosed |
| US-20190247513-A1 | CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2019-08-15 | — | — | US | disclosed |
| CN-103130760-B | Novel targeting antineoplastic drug and manufacture method thereof and application thereof | DALIAN CHEMICAL PHYSICS INST | 2015-06-17 | — | — | CN | disclosed |
| US-8846898-B2 | Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge | Lieure Cornu LLC (US) | 2014-09-30 | — | — | US | disclosed |
| CN-103130760-A | Novel targeting antineoplastic drug and manufacture method thereof and application thereof | DALIAN CHEMICAL PHYSICS INST | 2013-06-05 | — | — | CN | disclosed |
| US-20100311960-A1 | Phosphinoamidite Carboxylates and Analogs Thereof in the Synthesis of Oligonucleotide Having Reduced Internucleotide Charge | LIEVRE CORNU LLC (US) | 2010-12-09 | — | — | US | disclosed |
| US-7745591-B2 | phosphinocarboxylate and phosphonocarboxylate oligonucleotides having enhanced nuclease resistance | Lievre Cornu, LLC (US) | 2010-06-29 | — | — | US | disclosed |
| EP-1334111-A4 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | DELLINGER DOUGLAS J (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20060293511-A1 | phosphinocarboxylate and phosphonocarboxylate oligonucleotides having enhanced nuclease resistance | LIEVRE CORNU LLC (US) | 2006-12-28 | — | — | US | disclosed |
| US-7067641-B2 | Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge | LIEVRE CORNU LLC (US) | 2006-06-27 | — | — | US | disclosed |
| US-20040116687-A1 | oligonucleotides having reduced internucleotide charge and enhanced nuclease resistance | AGILENT TECHNOLOGIES, INC. | 2004-06-17 | — | — | US | disclosed |
| US-6693187-B1 | ENHANCING NUCLEASE RESISTANCE | LIEVRE CORNU LLC | 2004-02-17 | — | — | US | disclosed |
| EP-1334111-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | Dellinger, Douglas J. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002032912-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | DELLINGER DOUGLAS J (US) | 2002-04-25 | — | — | WO | disclosed |
| EP-0001290-B1 | SUBSTITUTED 2,3-DIHYDROBENZ-(D)-ISOTHIAZOLE-1,1-DIOXIDES AND 2,3-DIHYDRONAPHTHO-(1,8-DE)-1,2-THIAZINE-1,1-DIOXIDES | POLAROID CORPORATION (US) | 1984-06-27 | — | — | EP | disclosed |