Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 16/20 | 0.46 |
| ▸ | TP53 | P04637 | 7/20 | 0.45 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319797 | 0.88 | MDM2 (0.53) | MDM2TP53MDM4 | |
| SCHEMBL3250970 | 0.84 | MDM2 (0.49) | MDM2TP53 | |
| SCHEMBL3241327 | 0.83 | MDM2 (0.53) | MDM2TP53HTT | |
| SCHEMBL3252191 | 0.83 | MDM2 (0.53) | MDM2TP53HTT | |
| SCHEMBL3248187 | 0.82 | MDM2 (0.48) | MDM2TP53 | |
| SCHEMBL8210751 | 0.81 | MDM2 (0.51) | MDM2TP53 | |
| SCHEMBL1322410 | 0.79 | MDM2 (0.53) | MDM2TP53 | |
| SCHEMBL1321485 | 0.76 | MDM2 (0.56) | MDM2TP53 | |
| SCHEMBL1321538 | 0.76 | MDM2 (0.51) | MDM2TP53 | |
| SCHEMBL1322760 | 0.76 | MDM2 (0.56) | MDM2TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |