Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250970 | 0.88 | MDM2 (0.49) | MDM2TP53BCHEMAOBL3MBTL1 | |
| SCHEMBL3241327 | 0.87 | MDM2 (0.53) | MDM2TP53L3MBTL1KDM4EMEN1 | |
| SCHEMBL1319816 | 0.87 | MDM2 (0.50) | MDM2TP53KDM4E | |
| SCHEMBL3252191 | 0.86 | MDM2 (0.53) | MDM2TP53L3MBTL1KDM4EMEN1 | |
| SCHEMBL3239013 | 0.82 | MDM2 (0.46) | MDM2TP53 | |
| SCHEMBL1321485 | 0.80 | MDM2 (0.56) | MDM2TP53MAOBMEN1KMT2A | |
| SCHEMBL1322760 | 0.79 | MDM2 (0.56) | MDM2TP53KDM4EMEN1KMT2A | |
| SCHEMBL1325985 | 0.79 | MDM2 (0.55) | MDM2TP53L3MBTL1KDM4EMEN1 | |
| SCHEMBL1321538 | 0.78 | MDM2 (0.51) | MDM2TP53 | |
| SCHEMBL27875552 | 0.77 | MDM2 (0.51) | MDM2TP53KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |