Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319625 | 0.91 | MDM2 (0.52) | MDM2TP53DGAT2ALDH1A1KMT2A | |
| SCHEMBL3252191 | 0.89 | MDM2 (0.53) | MDM2TP53KDM4EKMT2AMEN1 | |
| SCHEMBL3239254 | 0.87 | MDM2 (0.49) | MDM2TP53KMT2AMEN1 | |
| SCHEMBL1322410 | 0.87 | MDM2 (0.53) | MDM2TP53DGAT2ALDH1A1KMT2A | |
| SCHEMBL1320670 | 0.87 | MDM2 (0.55) | MDM2TP53DGAT2ALDH1A1KDM4E | |
| SCHEMBL1321776 | 0.87 | MDM2 (0.61) | MDM2TP53DGAT2ALDH1A1KDM4E | |
| SCHEMBL1325985 | 0.86 | MDM2 (0.55) | MDM2TP53KDM4EKMT2AMEN1 | |
| SCHEMBL1320856 | 0.85 | MDM2 (0.51) | MDM2TP53DGAT2ALDH1A1KDM4E | |
| SCHEMBL1320616 | 0.84 | MDM2 (0.51) | MDM2TP53DGAT2ALDH1A1KDM4E | |
| SCHEMBL1322760 | 0.84 | MDM2 (0.56) | MDM2TP53KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |