Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 8/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240410 | 0.82 | HTT (0.61) | HTTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3239914 | 0.78 | CHRNB2 (0.67) | CHRNB2CHRNA4NR1H3CHRNA7 | |
| SCHEMBL7215289 | 0.76 | CHRNB2 (0.56) | CHRNB2CHRNA4NR1H3HDAC3HDAC4 | |
| SCHEMBL14012798 | 0.75 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNA7NR1D1 | |
| SCHEMBL13954259 | 0.75 | RECQL (0.48) | CHRNB2CHRNA4NR1H3NR1D1 | |
| SCHEMBL16606314 | 0.75 | CHRNB2 (0.69) | CHRNB2CHRNA4NR1H3CHRNA7NR1D1 | |
| SCHEMBL9827841 | 0.73 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL16211015 | 0.73 | CHRNA7 (0.54) | CHRNB2CHRNA4NR1H3HDAC3HDAC4 | |
| SCHEMBL8716866 | 0.73 | KMT2A (0.56) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL27928441 | 0.73 | CHRNA7 (0.58) | CHRNB2CHRNA4NR1H3HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | CHRNB2 3688/4885CHRNA4 4347/4885NR1H3 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.