Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 20/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 11/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 11/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 11/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235450 | 0.79 | CHRNA4 (0.61) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3232991 | 0.77 | CHRNA7 (0.60) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10037528 | 0.76 | CHRNA4 (1.00) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3231503 | 0.75 | CHRNA4 (0.62) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3231474 | 0.74 | CHRNA4 (0.62) | CHRNA4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3239241 | 0.73 | CHRNA4 (0.62) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10037485 | 0.73 | CHRNA4 (1.00) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3232448 | 0.72 | CHRNA4 (0.65) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3240393 | 0.72 | CHRNA4 (0.39) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3236644 | 0.70 | CHRNA4 (0.62) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |