SCHEMBL3240424

SCHEMBL3240424

CC[C](C#N)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.46
CES2 O00748 2/20 0.45
CES1 P23141 2/20 0.45
ALDH1A1 P00352 3/20 0.40
MAPT P10636 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
MAPK1 P28482 2/20 0.40
RAB9A P51151 2/20 0.40
LMNA P02545 2/20 0.40
XBP1 P17861 1/20 0.40
ESR1 P03372 2/20 0.39
CYP19A1 P11511 1/20 0.39
ESR2 Q92731 1/20 0.39
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
PTGS2 P35354 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9679821 0.85 CES2 (0.47) ATMCES2CES1ALDH1A1MAPT
SCHEMBL6117869 0.76 ESR1 (0.48) ATMCES2CES1ALDH1A1MAPT
SCHEMBL2770573 0.76 ATM (0.42) ATMCES2CES1ALDH1A1MAPT
SCHEMBL2768577 0.74 ATM (0.41) ATMCES2CES1ALDH1A1MAPT
SCHEMBL9625667 0.74 AKT1 (0.38) ALDH1A1MAPTNPSR1MAPK1RAB9A
SCHEMBL2767639 0.74 ATM (0.41) ATMCES2CES1ALDH1A1MAPT
SCHEMBL13990398 0.74 ATM (0.41) ATMCES2CES1ALDH1A1MAPT
SCHEMBL16245087 0.74 ESR1 (0.47) ATMCES2CES1ALDH1A1MAPT
SCHEMBL16245090 0.74 ESR1 (0.47) ATMCES2CES1ALDH1A1MAPT
SCHEMBL5879098 0.73 KMT2A (0.40) ATMCES2CES1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0477646-B1 Substituted 5-alkoxy-1,2,4-triazol-3-(thi)ones BAYER AG (DE) 1995-03-01 EP claimed
EP-0283876-B1 Substituted triazolinones BAYER AG (DE) 1994-07-20 EP claimed
EP-0586418-A1 SUBSTITUTED TRIAZOLINONES BAYER AG (DE) 1994-03-16 EP claimed
EP-0294666-B1 Substituted triazolinones BAYER AG (DE) 1994-02-16 EP claimed
EP-0431390-B1 Substituted triazolinones BAYER AG (DE) 1994-01-12 EP claimed
US-5276008-A Herbicides and plant growth regulators BAYER AKTIENGESELLSCHAFT (DE) 1994-01-04 US claimed
EP-0332991-B1 Substituted triazoles BAYER AG (DE) 1993-11-10 EP claimed
EP-0398096-B1 SUBSTITUTED TRIAZOLONES BAYER AG (DE) 1993-10-13 EP claimed
EP-0412358-B1 3-AMINO-5-AMINOCARBONYL-1,2,4-TRIAZOLE DERIVATIVES BAYER AG (DE) 1993-09-29 EP claimed
EP-0415196-B1 SUBSTITUTED 4,5-DIAMINO-1,2,4-TRIAZOL-3-(THI)ONES BAYER AG (DE) 1993-03-24 EP claimed
EP-0477646-A1 Substituted 5-alkoxy-1,2,4-triazol-3-(thi)ones BAYER AG (DE) 1992-04-01 EP claimed
US-5082490-A HERBICIDAL SUBSTITUTED 4,5-DIAMINO-1,2,4-TRIAZOL-3-(THI)ONES BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 US claimed
EP-0298371-B1 SUBSTITUTED TRIAZOLINONES BAYER AG (DE) 1991-10-02 EP claimed
US-5051517-A Reacting a chloroformidine hydrochloride with an oxamohydrazide, forming bonds between carbon and nitrogen and cyclization BAYER AKTIENGESELLSCHAFT (DE) 1991-09-24 US claimed
EP-0431390-A1 Substituted triazolinones BAYER AG (DE) 1991-06-12 EP claimed
EP-0415196-A2 Substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones BAYER AG (DE) 1991-03-06 EP claimed
EP-0412358-A1 3-Amino-5-aminocarbonyl-1,2,4-triazole derivatives BAYER AG (DE) 1991-02-13 EP claimed
EP-0398096-A1 Substituted triazolones BAYER AG (DE) 1990-11-22 EP claimed
EP-0332991-A1 Substituted triazoles BAYER AG (DE) 1989-09-20 EP claimed
EP-0283876-A2 Substituted triazolinones BAYER AG (DE) 1988-09-28 EP claimed