Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5969148 | 0.88 | ESRRG (0.60) | NPC1RAB9AHDAC2HDAC8HDAC6 | |
| SCHEMBL3231717 | 0.86 | KMT2A (0.65) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL3237723 | 0.86 | RAB9A (0.73) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL3232164 | 0.86 | ESRRG (0.59) | NPC1RAB9ASMN1; SMN2MAPTHDAC2 | |
| SCHEMBL14469162 | 0.83 | NPC1 (0.84) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL16900376 | 0.82 | RAB9A (1.00) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL5969191 | 0.82 | RAB9A (0.88) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL23832296 | 0.81 | HPGD (0.58) | NPC1RAB9APOLBSMN1; SMN2ESRRG | |
| SCHEMBL3233643 | 0.81 | TAAR1 (0.51) | NPC1RAB9APOLBMAPTTP53 | |
| SCHEMBL2412199 | 0.81 | HDAC1 (0.75) | NPC1RAB9AHDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022355-A1 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES | PURDUE RESEARCH FOUNDATION (US) | 2010-02-25 | — | — | WO | disclosed |