Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245633 | 0.87 | PRKAB2 (0.46) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL3249304 | 0.86 | NR4A2 (0.48) | CYP1A2HSD17B10KDM4EPRKAB2PRKAG1 | |
| SCHEMBL3248629 | 0.86 | MCL1 (0.50) | CYP1A2HSD17B10KDM4EPRKAB2PRKAG1 | |
| SCHEMBL3254828 | 0.85 | NPC1 (0.45) | CHEK1CYP1A2HSD17B10KDM4E | |
| SCHEMBL3250737 | 0.84 | CYP1A2 (0.41) | WEE1CHEK1CYP1A2HSD17B10KDM4E | |
| SCHEMBL3247597 | 0.83 | MCL1 (0.46) | WEE1CHEK1CYP1A2HSD17B10KDM4E | |
| SCHEMBL3241482 | 0.83 | WEE1 (0.39) | WEE1CYP1A2HSD17B10PRKAB2PRKAG1 | |
| SCHEMBL4165826 | 0.82 | HPGD (0.43) | WEE1CHEK1PARP1 | |
| SCHEMBL3241773 | 0.81 | NGFR (0.49) | CYP1A2HSD17B10KDM4EPARP1CSNK2A2 | |
| SCHEMBL3245137 | 0.81 | MCL1 (0.53) | BACE1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |