Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.48 |
| ▸ | SYK | P43405 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249134 | 0.85 | HRH1 (0.42) | GRM5CHRNA7 | |
| SCHEMBL3249369 | 0.82 | SYK (0.64) | GRM5SYKAURKBINCENPCHRNA7 | |
| SCHEMBL3245556 | 0.80 | KDM4E (0.47) | GRM5SYKAURKBINCENPHTR2C | |
| SCHEMBL23406003 | 0.80 | GRM5 (0.48) | GRM5SYKAURKBINCENPHTR2C | |
| SCHEMBL29744012 | 0.80 | GRM5 (0.48) | GRM5SYKAURKBINCENPHTR2C | |
| SCHEMBL1422442 | 0.74 | EPHB4 (0.55) | — | |
| SCHEMBL13661860 | 0.73 | SYK (0.54) | GRM5SYKAURKBINCENPHTR2C | |
| SCHEMBL4235232 | 0.73 | SYK (0.54) | GRM5SYKHTR2C | |
| SCHEMBL30716906 | 0.73 | SYK (0.54) | GRM5SYKHTR2C | |
| SCHEMBL11354880 | 0.73 | SMN1; SMN2 (0.51) | GRM5SYKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |