Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252457 | 0.93 | KDM4E (0.38) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3253991 | 0.91 | KDM4E (0.36) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3249082 | 0.90 | KDM4E (0.46) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| Hydrochloric Acid SCHEMBL3244592 | 0.90 | KDM4E (0.39) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3241913 | 0.90 | KDM4E (0.51) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3253823 | 0.88 | KDM4E (0.38) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3254795 | 0.88 | SIGMAR1 (0.42) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3250883 | 0.87 | RXFP1 (0.40) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3250472 | 0.86 | KDM4E (0.39) | KDM4EHPGDALDH1A1HSD17B10USP2 | |
| SCHEMBL3253929 | 0.86 | HSD17B10 (0.36) | KDM4EHPGDALDH1A1HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |