Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.69 |
| ▸ | RARG | P13631 | 10/20 | 0.69 |
| ▸ | RARA | P10276 | 8/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.61 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29802235 | 1.00 | RARB (0.69) | RARBRARGRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29357288 | 0.82 | RARG (1.00) | RARBRARGRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29357074 | 0.82 | RARG (1.00) | RARBRARGRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29727107 | 0.82 | RARG (1.00) | RARBRARGRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL174205 | 0.82 | RARG (1.00) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL8657238 | 0.80 | MEN1 (0.76) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL27425286 | 0.79 | MEN1 (0.67) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL7049678 | 0.79 | RARB (0.65) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL2406628 | 0.78 | RARB (0.60) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL6454889 | 0.78 | RARB (0.70) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130157260-A1 | IDENTIFICATION OF COMPOUNDS THAT REGULATE APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-06-20 | — | — | US | disclosed |
| US-8273705-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2012-09-25 | — | — | US | disclosed |
| US-20100292145-A1 | METHODS OF REGULATING APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2010-11-18 | — | — | US | disclosed |
| US-7745574-B2 | Compounds that regulate apoptosis | THE BURNHAM INSTITUTE (US) | 2010-06-29 | — | — | US | disclosed |
| WO-2008154207-A9 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20090215984-A1 | CONVERSION OF APOPTOTIC PROTEINS | THE BURNHAM INSTITUTE (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-7491700-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2009-02-17 | — | — | US | disclosed |
| WO-2008154207-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20070117753-A1 | CONVERSION OF APOPTOTIC PROTEINS | THE BURNHAM INSTITUTE (US) | 2007-05-24 | — | — | US | disclosed |
| US-20070054863-A1 | Compounds that regulate apoptosis | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
| US-7176277-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |
| WO-2006124537-A1 | COMPOUNDS THAT REGULATE APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2006-11-23 | — | — | WO | disclosed |
| US-20060193864-A1 | Conversion of apoptotic proteins | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-08-31 | — | — | US | disclosed |
| US-6994979-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2006-02-07 | — | — | US | disclosed |
| US-20040220097-A1 | Conversion of apoptotic proteins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-11-04 | — | — | US | disclosed |
| WO-2004052920-A9 | CONVERSION OF APOPTOTIC PROTEINS | BURNHAM INST (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004052920-A2 | CONVERSION OF APOPTOTIC PROTEINS | THE BURNHAM INSTITUTE (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | RARB 1796/4885RARG 2219/4885RARA 2968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.