⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15264610 | 0.79 | — | — | |
| SCHEMBL21555682 | 0.75 | KMT2A (0.44) | — | |
| SCHEMBL483937 | 0.73 | — | — | |
| SCHEMBL38507 | 0.73 | L3MBTL1 (0.45) | — | |
| SCHEMBL161241 | 0.73 | — | — | |
| SCHEMBL28257547 | 0.73 | L3MBTL1 (0.45) | — | |
| Hydrochloric Acid SCHEMBL4441902 | 0.71 | L3MBTL1 (0.44) | — | |
| SCHEMBL2039550 | 0.71 | — | — | |
| SCHEMBL757449 | 0.71 | — | — | |
| Calcium SCHEMBL31344979 | 0.71 | L3MBTL1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183444-A1 | MODULATORS OF PROTEIN KINASES | VIBLIOME THERAPEUTICS, LLC (US) | 2023-09-28 | — | — | WO | disclosed |
| EP-4026832-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Almac Discovery Limited (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3515897-B1 | PIPERAZINE CARBAMATES AS MODULATORS OF MAGL AND/OR ABHD6 AND THEIR USE | H LUNDBECK AS (DK) | 2021-08-18 | — | — | EP | disclosed |
| US-10766903-B2 | Piperidine derivatives as inhibitors of ubiquitin specific protease 7 | ALMAC DISCOVERY LIMITED (GB) | 2020-09-08 | — | — | US | disclosed |
| EP-3529241-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Almac Discovery Limited (GB) | 2019-08-28 | — | — | EP | disclosed |
| US-20190256518-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | GENETECH, INC. | 2019-08-22 | — | — | US | disclosed |
| CN-110088096-A | Piperidine derivatives as inhibitors of ubiquitin-specific protease 7 | 阿尔麦克探索有限公司 | 2019-08-02 | — | — | CN | disclosed |
| WO-2018073602-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | ALMAC DISCOVERY LIMITED (GB) | 2018-04-26 | — | — | WO | disclosed |
| EP-2838901-B1 | 6-(4-(1-AMINO-3-HYDROXYCYCLOBUTYL)PHENYL)-5-PHENYL(FURO, THIENO OR PYRROLO)[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES FOR THE TREATMENT OF CANCER | ALMAC DISCOVERY LTD (GB) | 2016-11-02 | — | — | EP | disclosed |
| US-9156853-B2 | AKT inhibitor compounds for treatment of cancer | ALMAC DISCOVERY LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| EP-2838901-A1 | 6- (4- (1 -AMINO- 3 -HYDROXYCYCLOBUTYL) PHENYL) - 5 - PHENYL (FURO, THIENO OR PYRROLO) [2, 3-D]PYRIMIDIN- 4 - ONE DERIVATIVES FOR THE TREATMENT OF CANCER | Almac Discovery Limited (GB) | 2015-02-25 | — | — | EP | disclosed |
| US-20150045377-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | US | disclosed |
| CN-104245705-A | 6- (4- (1-amino-3-hydroxycyclobutyl) phenyl) -5-phenyl (furo, thieno, or pyrrolo) [2, 3-d ] pyrimidin-4-one derivatives for the treatment of cancer | ALMAC DISCOVERY LTD | 2014-12-24 | — | — | CN | disclosed |
| WO-2013140189-A1 | 6- (4- (1 -AMINO- 3 -HYDROXYCYCLOBUTYL) PHENYL) - 5 - PHENYL (FURO, THIENO OR PYRROLO) [2, 3-D] PYRIMIDIN- 4 - ONE DERIVATIVES FOR THE TREATMENT OF CANCER | ALMAC DISCOVERY LIMITED (GB) | 2013-09-26 | — | — | WO | disclosed |
| CN-102558116-A | 2-halofuryl/thienyl-3-carboxamides | BAYER CROPSCIENCE AG | 2012-07-11 | — | — | CN | disclosed |
| US-7745483-B2 | 2-Halofuryl-thienyl-3-carboxamides | BAYER CROPSCIENCE AG (DE) | 2010-06-29 | — | — | US | disclosed |
| US-20080064874-A1 | 2-Halofuryl/Thienyl-3-Carboxamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | US | disclosed |
| CN-1956973-A | 2-halofuryl/thienyl-3-carboxamides | BAYER CROPSCIENCE AG (DE) | 2007-05-02 | — | — | CN | disclosed |
| EP-1713789-A1 | 2-HALOFURYL/THIENYL-3-CARBOXAMIDES | Bayer CropScience Aktiengesellschaft (DE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075452-A1 | 2-HALOFURYL/THIENYL-3-CARBOXAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-08-18 | — | — | WO | disclosed |