Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 15/20 | 0.54 |
| ▸ | TP53 | P04637 | 12/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27753713 | 0.92 | MDM2 (0.52) | MDM2TP53MAOBPGR | |
| SCHEMBL27753811 | 0.86 | MDM2 (0.53) | MDM2TP53MAOBPGR | |
| SCHEMBL27774432 | 0.85 | MDM2 (0.56) | MDM2TP53MAOBPGR | |
| SCHEMBL1319361 | 0.81 | MDM2 (0.52) | MDM2TP53MAOBPGR | |
| SCHEMBL1319835 | 0.79 | MDM2 (0.49) | MDM2TP53MAOB | |
| SCHEMBL27875560 | 0.78 | MDM2 (0.65) | MDM2TP53MAOBPGR | |
| SCHEMBL8203035 | 0.78 | MDM2 (0.60) | MDM2TP53MAOBPGRNR3C2 | |
| SCHEMBL1322276 | 0.78 | MDM2 (0.57) | MDM2TP53MAOBPGRNR3C2 | |
| SCHEMBL1321543 | 0.77 | MDM2 (0.48) | MDM2TP53MAOB | |
| SCHEMBL1319495 | 0.77 | MDM2 (0.54) | MDM2TP53MAOBPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |