Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242728 | 1.00 | KDM4E (0.45) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3242729 | 1.00 | KDM4E (0.45) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3245428 | 0.90 | BRD4 (0.44) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3246034 | 0.89 | KDM4E (0.44) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL13928189 | 0.89 | BRD4 (0.44) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3242978 | 0.87 | KDM4E (0.50) | KDM4EHTTMAPTHSD17B10GAA | |
| SCHEMBL4161880 | 0.86 | BRD4 (0.43) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL4717664 | 0.85 | BRD4 (0.46) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3247885 | 0.84 | BRD4 (0.44) | KDM4EBRD4HTTMAPTHSD17B10 | |
| SCHEMBL3246028 | 0.84 | KDM4E (0.44) | KDM4EHTTMAPTHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685091-B1 | M-DIAMINOBENZOLES AND THE ACIDIC ADDUCTS THEREOF AND USE THEREOF IN COLOURING AGENTS | PROCTER & GAMBLE (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |