Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4161883 | 0.94 | BRD4 (0.45) | BRD4JAK2JAK1JAK3KDM4E | |
| Butyric Acid SCHEMBL4162687 | 0.94 | BRD4 (0.45) | BRD4JAK2JAK1JAK3KDM4E | |
| SCHEMBL3242979 | 0.85 | KDM4E (0.45) | BRD4JAK2JAK1JAK3KDM4E | |
| SCHEMBL3242729 | 0.85 | KDM4E (0.45) | BRD4JAK2JAK1JAK3KDM4E | |
| SCHEMBL3242728 | 0.85 | KDM4E (0.45) | BRD4JAK2JAK1JAK3KDM4E | |
| SCHEMBL3245428 | 0.84 | BRD4 (0.44) | BRD4JAK2JAK1JAK3KDM4E | |
| SCHEMBL3261316 | 0.83 | BRD4 (0.44) | BRD4JAK2JAK1JAK3NAMPT | |
| SCHEMBL31129982 | 0.82 | BRD4 (0.47) | BRD4JAK2JAK1JAK3MEN1 | |
| SCHEMBL31130027 | 0.82 | BRD4 (0.47) | BRD4JAK2JAK1JAK3MEN1 | |
| SCHEMBL31129899 | 0.81 | BRD4 (0.47) | BRD4JAK2JAK1JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |