⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615857 | 0.71 | — | — | |
| SCHEMBL3125349 | 0.71 | — | — | |
| SCHEMBL12387894 | 0.67 | CCR4 (0.35) | — | |
| SCHEMBL29022955 | 0.66 | — | — | |
| SCHEMBL21121844 | 0.57 | TTR (0.48) | — | |
| SCHEMBL19837522 | 0.55 | MBOAT4 (0.37) | — | |
| SCHEMBL3367038 | 0.54 | — | — | |
| SCHEMBL1821091 | 0.54 | — | — | |
| SCHEMBL9797553 | 0.52 | PSMB8 (0.50) | — | |
| SCHEMBL31174409 | 0.52 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3864009-B1 | TYK2 KINASE INHIBITORS | SAREUM LTD (GB) | 2025-02-19 | — | — | EP | disclosed |
| US-12187716-B2 | TYK2 kinase inhibitors | SAREUM LIMITED (GB) | 2025-01-07 | — | — | US | disclosed |
| CN-113056456-B | TYK2 kinase inhibitors | 萨勒姆有限公司 | 2023-06-13 | — | — | CN | disclosed |
| US-20210387981-A1 | TYK2 KINASE INHIBITORS | SAREUM LIMITED (GB) | 2021-12-16 | — | — | US | disclosed |
| EP-3864009-A1 | TYK2 KINASE INHIBITORS | Sareum Limited (GB) | 2021-08-18 | — | — | EP | disclosed |
| CN-113056456-A | TYK2 kinase inhibitors | 萨勒姆有限公司 | 2021-06-29 | — | — | CN | disclosed |
| EP-2170849-B1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LTD (GB) | 2016-12-21 | — | — | EP | disclosed |
| US-9187465-B2 | Oxazole tyrosine kinase inhibitors | SAREUM LIMITED (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20150057282-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2015-02-26 | — | — | US | disclosed |
| US-8921544-B2 | Oxazole tyrosine kinase inhibitors | SAREUM LIMITED (GB) | 2014-12-30 | — | — | US | disclosed |
| US-20140275041-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2014-09-18 | — | — | US | disclosed |
| US-20130102592-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2013-04-25 | — | — | US | disclosed |
| US-8378095-B2 | Oxazole tyrosine kinase inhibitors | Saruem Limited (GB) | 2013-02-19 | — | — | US | disclosed |
| US-20100298301-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2010-11-25 | — | — | US | disclosed |
| WO-2010055304-A2 | PHARMACEUTICAL COMPOUNDS | SAREUM LIMITED (GB) | 2010-05-20 | — | — | WO | disclosed |
| EP-2170849-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | Sareum Limited (GB) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008139161-A1 | OXAZOLE TYROSINE KINASE INHIBITORS | SAREUM LIMITED (GB) | 2008-11-20 | — | — | WO | disclosed |