Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521725 | 0.94 | CYP11B1 (0.47) | TSHRCYP11B1TAAR1CYP11B2MAPT | |
| SCHEMBL3251460 | 0.92 | CHRM4 (0.42) | GRIN2BTSHRCYP11B1TAAR1CYP11B2 | |
| SCHEMBL3119024 | 0.92 | TAAR1 (0.46) | TSHRCYP11B1TAAR1MAPTALDH1A1 | |
| SCHEMBL13521598 | 0.91 | HSD17B3 (0.43) | GRIN2BTSHRCYP11B1TAAR1CYP11B2 | |
| SCHEMBL3244950 | 0.89 | TSHR (0.42) | TSHRGAATAAR1MAPTALDH1A1 | |
| SCHEMBL3246133 | 0.89 | MAPT (0.44) | TSHRCYP11B1TAAR1CYP11B2MAPT | |
| SCHEMBL3252487 | 0.89 | CYP11B1 (0.51) | CYP11B1TAAR1CYP11B2MAPTALDH1A1 | |
| SCHEMBL3248554 | 0.88 | ESR2 (0.41) | TSHRCYP11B1TAAR1CYP11B2MAPT | |
| SCHEMBL3246260 | 0.88 | CYP11B1 (0.48) | CYP11B1TAAR1CYP11B2MAPTALDH1A1 | |
| SCHEMBL3127545 | 0.87 | MAPK1 (0.41) | TSHRCYP11B1TAAR1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |