Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239822 | 0.91 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3249911 | 0.82 | MAPT (0.57) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL3256327 | 0.81 | PDE2A (0.38) | HSP90AA1HSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3246149 | 0.80 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1ALDH1A1HTR7KDM4E | |
| SCHEMBL3257237 | 0.70 | MAPT (0.41) | HSP90AA1HSP90AB1HTR7KDM4EMAPT | |
| SCHEMBL28668869 | 0.68 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ALDH1A1HTR7 | |
| SCHEMBL28148154 | 0.66 | CA1 (0.65) | ALDH1A1KMT2AMEN1L3MBTL1NQO2 | |
| SCHEMBL3244019 | 0.66 | TLR8 (0.40) | HSP90AA1HSP90AB1KMT2AMEN1KDM4E | |
| SCHEMBL14450978 | 0.66 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL9910949 | 0.66 | CCR1 (0.58) | HSP90AA1HSP90AB1HTR7NQO2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |