Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tiagabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 known ✓ | P30531 | 8/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.89 |
| ▸ | PDE4A | P27815 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiagabine SCHEMBL1527642 | 0.96 | SLC6A1 (0.98) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL5164417 | 0.95 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL7346237 | 0.95 | SLC6A1 (0.98) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL18496408 | 0.95 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL41860 | 0.95 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL17493682 | 0.95 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL3272861 | 0.94 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL34653 | 0.94 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL342814 | 0.94 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4AALDH1A1LMNA | |
| Tiagabine SCHEMBL3958156 | 0.93 | SLC6A1 (0.98) | SLC6A1PTGS1PDE4AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066656-A1 | Novel stable polymorphic forms of an anticonvulsant | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2007-03-22 | — | — | US | claimed |
| WO-2005122698-A2 | NOVEL STABLE POLYMORPHIC FORMS OF TIAGABINE HYDROCHLORIDE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2005-12-29 | — | — | WO | claimed |
| US-7667042-B2 | Amorphous form of tiagabine hydrochloride; epilepsy | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2010-02-23 | — | — | US | disclosed |
| US-20070066656-A1 | Novel stable polymorphic forms of an anticonvulsant | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2007-03-22 | — | — | US | disclosed |
| WO-2005122698-A2 | NOVEL STABLE POLYMORPHIC FORMS OF TIAGABINE HYDROCHLORIDE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2005-12-29 | — | — | WO | disclosed |