Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.90 |
| ▸ | JAK2 | O60674 | 7/20 | 0.90 |
| ▸ | MAP4K3 | Q8IVH8 | 7/20 | 0.90 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.90 |
| ▸ | JAK3 | P52333 | 4/20 | 0.90 |
| ▸ | JAK1 | P23458 | 3/20 | 0.90 |
| ▸ | TYK2 | P29597 | 3/20 | 0.90 |
| ▸ | PLK4 | O00444 | 2/20 | 0.90 |
| ▸ | AURKA | O14965 | 2/20 | 0.90 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.90 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.90 |
| ▸ | ABL1 | P00519 | 2/20 | 0.90 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.90 |
| ▸ | INSR | P06213 | 2/20 | 0.90 |
| ▸ | LCK | P06239 | 2/20 | 0.90 |
| ▸ | FES | P07332 | 2/20 | 0.90 |
| ▸ | CSF1R | P07333 | 2/20 | 0.90 |
| ▸ | LYN | P07948 | 2/20 | 0.90 |
| ▸ | RET | P07949 | 2/20 | 0.90 |
| ▸ | IGF1R | P08069 | 2/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1582209 | 1.00 | MET (0.90) | METJAK2MAP4K3ALKJAK3 | |
| Acetic Acid SCHEMBL16324188 | 0.95 | MET (0.82) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL28844303 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL30129754 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL94020 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL29831970 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL28844302 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL29351506 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL93829 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 | |
| Crizotinib SCHEMBL29622387 | 0.95 | MET (1.00) | METJAK2MAP4K3ALKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786785-B9 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |