Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | FRK | P42685 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | MST1R | Q04912 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244253 | 0.69 | BACE1 (0.40) | HDAC4MALT1SMARCA2SMARCA4SYK | |
| SCHEMBL3244258 | 0.66 | HDAC4 (0.37) | HDAC4OPRM1OPRL1SYK | |
| SCHEMBL3616240 | 0.60 | SMARCA2 (0.66) | HDAC4MALT1SMARCA2SMARCA4 | |
| SCHEMBL3239041 | 0.58 | BACE1 (0.36) | OPRM1OPRL1SYK | |
| SCHEMBL2463393 | 0.58 | BACE1 (0.58) | — | |
| SCHEMBL3239035 | 0.58 | BACE1 (0.52) | OPRM1OPRL1SYK | |
| SCHEMBL29769017 | 0.57 | LOXL2 (0.52) | HDAC4SMARCA2SMARCA4SYK | |
| SCHEMBL1199840 | 0.57 | LOXL2 (0.52) | HDAC4SMARCA2SMARCA4SYK | |
| SCHEMBL31644090 | 0.56 | SMARCA2 (0.42) | HDAC4SMARCA2SMARCA4 | |
| SCHEMBL27597129 | 0.55 | SYK (0.50) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056195-A1 | NEW COMPOUNDS 575 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |