Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236643 | 0.87 | SCN9A (0.60) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3249796 | 0.79 | SCN9A (0.66) | SCN9ASCN5AKCNH2 | |
| SCHEMBL3243244 | 0.79 | SCN9A (0.53) | SCN9ASCN5AKCNH2 | |
| SCHEMBL3251227 | 0.78 | SCN9A (0.67) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3247193 | 0.77 | SCN9A (0.54) | SCN9ASCN5AKCNH2 | |
| SCHEMBL3249851 | 0.76 | SCN9A (0.60) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3244151 | 0.75 | SCN9A (0.70) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3244971 | 0.75 | SCN9A (0.63) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3244935 | 0.75 | SCN9A (0.59) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3254123 | 0.74 | SCN9A (0.65) | SCN9ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |