Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252740 | 0.92 | SCN9A (0.53) | SCN9AKCNH2SCN5AEGLN2 | |
| SCHEMBL3249796 | 0.89 | SCN9A (0.66) | SCN9AKCNH2SCN5ABTK | |
| SCHEMBL3242507 | 0.87 | SCN9A (0.52) | SCN9AKCNH2SCN5A | |
| SCHEMBL3249539 | 0.86 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3243244 | 0.81 | SCN9A (0.53) | SCN9AKCNH2SCN5A | |
| SCHEMBL3250238 | 0.79 | SCN9A (0.52) | SCN9AKCNH2SCN5A | |
| SCHEMBL3239053 | 0.77 | SCN9A (0.77) | SCN9AKCNH2SCN5A | |
| SCHEMBL3244478 | 0.77 | SCN9A (0.54) | SCN9AKCNH2SCN5A | |
| SCHEMBL3245789 | 0.76 | SCN9A (0.63) | SCN9AKCNH2SCN5A | |
| SCHEMBL3246913 | 0.76 | SCN9A (0.65) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |