Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247413 | 0.85 | ROCK2 (0.55) | ROCK2ROCK1CYP2C9CDC42BPA | |
| SCHEMBL3253617 | 0.80 | ROCK2 (0.57) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3252562 | 0.79 | ROCK2 (0.56) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3130772 | 0.79 | ROCK2 (0.55) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3255476 | 0.79 | ROCK2 (0.59) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3239746 | 0.79 | ROCK2 (0.56) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3245593 | 0.78 | ROCK2 (0.53) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3244488 | 0.77 | ROCK2 (0.57) | ROCK2ROCK1CYP2C9CDC42BPA | |
| SCHEMBL3246520 | 0.77 | ROCK2 (0.59) | ROCK2ROCK1CYP2C9CDC42BPA | |
| SCHEMBL3246278 | 0.77 | ROCK2 (0.44) | ROCK2ROCK1CDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |