⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28410363 | 0.74 | — | — | |
| SCHEMBL11215921 | 0.73 | — | — | |
| SCHEMBL16113551 | 0.73 | — | — | |
| SCHEMBL28599883 | 0.72 | — | — | |
| SCHEMBL3643389 | 0.71 | — | — | |
| SCHEMBL10667994 | 0.70 | — | — | |
| SCHEMBL7234828 | 0.68 | — | — | |
| SCHEMBL28096060 | 0.68 | — | — | |
| SCHEMBL5495187 | 0.67 | — | — | |
| SCHEMBL7032346 | 0.66 | SMN1; SMN2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696244-B2 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| US-20070265316-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-15 | — | — | US | disclosed |
| WO-2004110352-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-12-23 | — | — | WO | disclosed |
| US-6514967-B1 | For reducing greater than normal concentrations of extra cellular glutamate in warm-blooded animals | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2003-02-04 | — | — | US | disclosed |
| EP-0984953-A1 | COMPOUND FOR PREPARING MEDICINES FOR TREATING PATHOLOGIES INVOLVING EXTRACELLULAR GLUTAMATE, AND METHODS FOR OBTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998052936-A1 | COMPOUND FOR PREPARING MEDICINES FOR TREATING PATHOLOGIES INVOLVING EXTRACELLULAR GLUTAMATE, AND METHODS FOR OBTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-11-26 | — | — | WO | disclosed |
| US-4737515-A | Use of tetrahydrobenzothienylurea derivatives as fungicides | BAYER AKTIENGESELLSCHAFT (DE) | 1988-04-12 | — | — | US | disclosed |