SCHEMBL3244682

SCHEMBL3244682

COc1cccc(COC(=O)Nc2ccc(-c3cn[nH]c3)cc2NCCN(C)C)c1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 18/20 0.57
ROCK1 Q13464 10/20 0.55
CYP2C9 P11712 3/20 0.55
CDC42BPA Q5VT25 3/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2D6 P10635 2/20 0.55
PRKACA P17612 1/20 0.49
PRKACG P22612 1/20 0.49
PRKACB P22694 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3239730 0.89 ROCK2 (0.59) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3124355 0.86 ROCK2 (0.76) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3119265 0.86 ROCK2 (0.66) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL13390999 0.86 ROCK2 (0.62) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3255470 0.86 ROCK2 (0.74) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL13391300 0.85 ROCK2 (0.59) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3249281 0.84 ROCK2 (0.55) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3252693 0.82 ROCK2 (0.65) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3244989 0.81 ROCK2 (0.64) ROCK2ROCK1CYP2C9CDC42BPACYP3A4
SCHEMBL3248264 0.80 ROCK2 (0.62) ROCK2ROCK1CYP2C9CDC42BPACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010036316-A1 UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS FENG YANGBO (US) 2010-04-01 WO claimed
WO-2010036316-A1 UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS FENG YANGBO (US) 2010-04-01 WO disclosed
WO-2010036316-A1 UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS FENG YANGBO (US) 2010-04-01 WO disclosed