Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245835 | 0.87 | TRPV1 (0.41) | TRPV1MAPTKMT2AALDH1A1CSF1R | |
| SCHEMBL3251646 | 0.87 | MAP4K4 (0.40) | SCN9APARP1 | |
| SCHEMBL3243042 | 0.86 | CYP17A1 (0.41) | SCN9APARP1TACR1 | |
| SCHEMBL3249063 | 0.85 | CDK2 (0.39) | TRPV1METAP2TYMSKDM4EBACE1 | |
| SCHEMBL3254005 | 0.82 | TRPV1 (0.43) | TRPV1SCN9ATLR9TLR8TLR7 | |
| SCHEMBL3244660 | 0.82 | TYMS (0.37) | SCN9AMAPTSMN1; SMN2TYMSKMT2A | |
| SCHEMBL3254886 | 0.82 | PAK1 (0.42) | MAPTSMN1; SMN2TYMSKMT2AALDH1A1 | |
| SCHEMBL3263410 | 0.81 | TYMS (0.40) | MAPTSMN1; SMN2TYMSKMT2AALDH1A1 | |
| SCHEMBL3252380 | 0.81 | CSF1R (0.43) | SCN9AMAPTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4160163 | 0.81 | TRPV1 (0.41) | TRPV1SCN9AMAPTSMN1; SMN2TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |