Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249846 | 0.86 | KDM4E (0.46) | CDK2CDK1IRAK4METAP2MCL1 | |
| SCHEMBL3249440 | 0.86 | MMP2 (0.39) | TSHRBRD4LMNA | |
| SCHEMBL3244744 | 0.85 | TRPV1 (0.40) | METAP2KDM4ETRPV1BACE1TYMS | |
| SCHEMBL3244660 | 0.84 | TYMS (0.37) | CDK1HSD17B10KDM4ETSHRTYMS | |
| SCHEMBL3254886 | 0.84 | PAK1 (0.42) | HSD17B10KDM4ETSHRTYMSLMNA | |
| SCHEMBL3254540 | 0.84 | MMP2 (0.46) | HSD17B10KDM4EBRD4 | |
| SCHEMBL3263410 | 0.84 | TYMS (0.40) | CDK1MCL1KDM4EBACE1TYMS | |
| SCHEMBL3252380 | 0.83 | CSF1R (0.43) | HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL3243041 | 0.82 | WEE1 (0.38) | HSD17B10KDM4EBRD4LMNA | |
| SCHEMBL3250925 | 0.81 | NR1H2 (0.38) | HSD17B10KDM4ETSHRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |