Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12165522 | 0.85 | ATM (0.77) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL24281081 | 0.76 | SMN1; SMN2 (0.62) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL31453077 | 0.73 | GAA (0.61) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL15229056 | 0.73 | GAA (0.61) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL15229055 | 0.73 | GAA (0.61) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL31453076 | 0.73 | GAA (0.61) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL8056975 | 0.73 | GAA (0.61) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL1460831 | 0.72 | SMN1; SMN2 (0.70) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL4067986 | 0.72 | GAA (0.59) | ATMSMN1; SMN2HTTGAAIDO1 | |
| SCHEMBL11375291 | 0.71 | ATM (0.57) | ATMSMN1; SMN2HTTGAAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516366-B | Oxindole derivatives as anticancer agents | HOFFMANN LA ROCHE | 2012-05-30 | — | — | CN | claimed |
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | disclosed |