Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Calcitriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | GC | P02774 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | RXRA | P19793 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calcitriol SCHEMBL3488822 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL2641696 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL2733051 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL15169024 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL24066838 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL14027727 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL23386523 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL13989116 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL17973736 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 | |
| Calcitriol SCHEMBL21055106 | 1.00 | VDR (1.00) | VDRMAPTADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33680 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739320-A1 | ANTI-CANCER EFFECT OF THE COMBINATION OF SODIUM PENTABORATE PENTAHIDRATE AND VITAMIN D ACTIVE FORM CALCITRIOL AGAINST HEPATOCELLULAR CARCINOMA | Yeditepe Universitesi (TR) | 2026-05-13 | — | — | EP | claimed |
| US-12616749-B2 | Methods for treatment of psoriasis with an anti-oxLDL antibody | ABCENTRA, LLC (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026085644-A1 | FLOATING RIGID CAGE | BUSCHMANN SCHIRMER WALTER FRANCISCO (CL) | 2026-04-30 | — | — | WO | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| EP-4732908-A2 | CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS | Biomed Valley Discoveries, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| US-20260096581-A1 | FISH BONE POWDER, AND METHOD AND DEVICE FOR PREPARING THE SAME | NATIONAL PINGTUNG UNIV OF SCIENCE AND TECHNOLOGY (TW) | 2026-04-09 | — | — | US | claimed |
| EP-4720259-A2 | METHODS AND USES OF DIFFERENTIATED CELLS | Miromatrix Medical Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| US-20260091015-A1 | TREATING IRON DEFICIENCY WITH FERRIC CARBOXYMALTOSE | PHARMACOSMOS HOLDING AS (DK) | 2026-04-02 | — | — | US | claimed |
| US-20260083673-A1 | OIL-IN-WATER EMULSIONS FOR TOPICAL ADMINISTRATION AND USES THEREOF | INST NAT SANTE RECH MED (FR) | 2026-03-26 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-0042673-B1 | CYTORECEPTOR ASSAY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1986-03-26 | — | — | EP | claimed |
| WO-1984004527-A1 | PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS | WISCONSIN ALUMNI RES FOUND (US) | 1984-11-22 | — | — | WO | claimed |
| US-4481356-A | MEDICAL DIAGNOSIS | THE UPJOHN COMPANY (US) | 1984-11-06 | — | — | US | claimed |
| EP-0086476-A2 | Utilization of cholecalciferol derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-08-24 | — | — | EP | claimed |
| US-4330537-A | PHOSPHONATE COMPOUNDS AND VITAMIN D DERIVATIVES USEFUL AGAINST OSTEOPORSIS | THE PROCTER & GAMBLE COMPANY (US) | 1982-05-18 | — | — | US | claimed |
| EP-0042673-A1 | Cytoreceptor assay | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1981-12-30 | — | — | EP | claimed |
| US-4308264-A | PREVENTION OF HYDOCALCEMIA | ABBOTT LABORATORIES (US) | 1981-12-29 | — | — | US | claimed |
| US-4305935-A | VITAMIN D3 DERIVATIVE AND ACETYLSALICYLIC ACID USEFUL AGAINST THE DISEASES CAUSED BY VITAMIN D DEFICIENCY | TEIJIN LIMITED (JP) | 1981-12-15 | — | — | US | claimed |
| US-4230700-A | ADMINISTERING AN ORGANIC MONO- OR DIPHOSPHONATE AND A VITAMIN-D-LIKE ANTIRACHITIC COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1980-10-28 | — | — | US | claimed |
| US-4012509-A | HYDROXY-CHOLECALCIFEROLS, -TACHYSTEROLS, -ERGOCALCIFEROLS AND THEIR ACYLATES; EGG SHELL THICKNESS | THE UPJOHN COMPANY (US) | 1977-03-15 | — | — | US | claimed |